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| | "Get on a life support system. There have been cases where people have survived," Jon-Paul says helpfully.Biological 'kit bag'It is quite an overkill for a little marine animal whose usual dinner is no bigger than a goldfish, but what grips scientists is not the potency of its venom but the complexity. "These snails will produce millions of changes in their toxins that they use to kill their prey," Jon-Paul tells the BBC Radio 4 programme Danger! Venomous Snails. "If they don't make these changes,Michael Kors Outlet, they can be at an evolutionary disadvantage, so the snails have become good pharmaceutical chemists. It is these compounds that we are trying to harness to use as specific medicines."One of these compounds is already at work. Just over a year ago, the US Federal Drug Agency approved the first of a new type of painkiller - Prialt? - which can work in cases where ordinary drugs fail. The drug has also been approved for use in Europe.It blocks a particular channel in nerves which communicates pain signals to the brain. The original toxin behind the drug was discovered in the lab of Professor Baldomero Olivera,Michael Kors Outlet, at the University of Utah, and he's excited about the future. "There's an explosion of data about neuroscience and what can go wrong," he says."We'd like to understand and affect many different molecules in the normal brain. Using very specific toxins that wipe out the function of just one thing in the nervous system, lets us do that. "We see applications in epilepsy, stroke and cardiovascular conditions. Some are in development and one has reached clinical trials." Just the beginningAnother way of stopping strokes and heart attacks is to cut down on smoking. Snail toxins might help here, too. Professor Bruce Livett, of the University of Melbourne,Michael Kors, Australia, is looking at how they affect the nicotinic receptor - the very thing that gets a hit when you puff on a cigarette. A drug to inhibit that might help you stop smoking, but this research is already tackling severe pain in diabetic patients. There could even be applications in Alzheimer's or Parkinson's disease, says Bruce, but one thing bothers him: we should take time to get to know the snail, not just its venom."There's a whole world of invertebrate biology out there far more advanced than our own mammalian biology," he says.That is where Jon-Paul Bingham's work has been important. By developing his way of milking the snails,Michael Kors Outlet, Jon-Paul keeps the animals alive in his lab and learns more about them. He does not need to dissect the "goose that lays the golden egg" to study its venom,Michael Kors Handbags. He analyses their venoms and then synthesises the compounds he finds for further work. His hope is to set up a library of venoms to help other researchers get access to this field. He sees potential for snail toxins to be used in everything from agriculture to anti-fouling paints against marine worms. Cone shells research appears to be advancing much more quickly than your average snail. |
