If you did that, you would be helping to counteract one of the most corrosive and invidious in the nonprofit sector: the idea that it's incredibly important to look at the "overhead ratio", and give only to charities which spend a small proportion of their money on overhead, and a large proportion of their money on program activities. It really isn't. But partly because a lot of people think that it is, this year I gave to , the Drugs for Neglected Diseases initiative, an amazing nonprofit which is basically all overhead. Its job is to coordinate the work of organizations all over the world, from non-profits to pharmaceutical companies to multilateral organizations to national health ministries, and to get them all working together to create drug cocktails which can cure devastating diseases in some of the most forlorn parts of the world.